IMMUNOBIOLOGY Restriction of HIV-1 replication in macrophages and CD4 T cells from HIV controllers
نویسندگان
چکیده
1Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France; 2Assistance Publique–Hopiteux de Paris (AP-HP), Centre Hospitalier Universitaire (CHU) Necker-Enfants Malades, Laboratoire de Virologie, Paris, France; 3Inserm U1018, Hôpital Bicêtre, Le Kremlin-Bicêtre, France; 4Inserm U1012, Le Kremlin-Bicêtre, France; 5AP-HP, Hôpital Bicêtre, Service de Médecine Interne et Maladies Infectieuses, Le Kremlin-Bicêtre, France; and 6Université Paris-Descartes, Faculté de Médecine, Paris, France
منابع مشابه
Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers.
How HIV controllers (HICs) maintain undetectable viremia without therapy is unknown. The strong CD8(+) T-cell HIV suppressive capacity found in many, but not all, HICs may contribute to long-lasting viral control. However, other earlier defense mechanisms may be involved. Here, we examined intrinsic HIC cell resistance to HIV-1 infection. After in vitro challenge, monocyte-derived macrophages a...
متن کاملAssessment of HTLV-I proviral load, HIV viral load and CD4 T cell count in infected subjects; with an emphasis on viral replication in co-infection
Objective(s): HTLV-I and HIV virus quantification is an important marker for assessment of virus activities. Since there is a direct relationship between the number of virus and disease progression, HTLV- I and HIV co-infection might have an influence on the development of viral associated diseases, thus, viral replication of these viruses and co-infection were evaluated. Materials and...
متن کاملComparative analysis of the capacity of elite suppressor CD4+ and CD8+ T cells to inhibit HIV-1 replication in monocyte-derived macrophages.
UNLABELLED Elite controllers or suppressors (ESs) are HIV-1-infected individuals who are able to maintain viral loads below the limit of detection of clinical assays without antiretroviral therapy. The mechanisms of virologic control are not fully understood, but ESs have been shown to have a more effective CD8+ T cell response to infected CD4+ T cells than chronic progressors (CPs). While macr...
متن کاملIncreased expression of SAMHD1 in a subset of HIV-1 elite controllers.
OBJECTIVES SAMHD1 and the CDKN1A (p21) cyclin-dependent kinase inhibitor have been postulated to mediate HIV-1 restriction in CD4+ cells. We have shown that p21 affects HIV replication through its effect on SAMHD1. Thus, we aimed at evaluating the expression of SAMHD1 and p21 in different HIV+ phenotypic groups. PATIENTS AND METHODS We evaluated SAMHD1 and CDKN1A mRNA expression in CD4+ T cel...
متن کاملMacrophage HIV-1 infection and the gastrointestinal tract reservoir.
Excluding parenteral transmissions, virtually all vertical and homosexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs via the gastrointestinal tract. Cellular routes implicated in the translocation of virus across the epithelium include M cells, dendritic cells, and epithelial cells. Intestinal epithelial cells express CCR5 and can selectively transfer CCR5-tropic HIV-1, ...
متن کامل